Mikel Arteta's Arsenal welcome another of his former clubs - Everton - to the Emirates Stadium in the Premier League. A tightly fought reverse fixture at Goodison ended 0-0.
Chelsea and Bayern Munich meet in the Champions League Round of 16 first leg at Stamford Bridge.
Manchester City travel to the Santiago Bernabeu to take on Real Madrid in the first leg of their UEFA Champions League Round of 16 match.
Lyon and Juventus meet in the UEFA Champions League at Parc Olympique Lyonnais as they play their Round of 16 first leg tie.